Seroatlas · Human Serome Atlas

PGC

Gastricsin

Also known as: PEPC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20142
Gene
PGC
Ensembl
ENSG00000096088
Chromosome
6
Canonical length
388 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location
Nucleoplasm
Secretome location
Secreted to digestive system

OverviewNCBI Gene

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>P20142|PGC
     1  MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP AWKYRFGDLS
    61  VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP SVYCQSQACT SHSRFNPSES
   121  STYSTNGQTF SLQYGSGSLT GFFGYDTLTV QSIQVPNQEF GLSENEPGTN FVYAQFDGIM
   181  GLAYPALSVD EATTAMQGMV QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY
   241  WAPVTQELYW QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE
   301  DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT YLSSQNGQPL
   361  WILGDVFLRS YYSVYDLGNN RVGFATAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
57,584 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 57,584 nTPM
  • duodenum: 1,253 nTPM
  • seminal vesicle: 413 nTPM
  • lung: 349 nTPM
  • pancreas: 120 nTPM
  • prostate: 73 nTPM

Single-cell type

  • gastric chief cells: 125,642 nCPM
  • parietal cells: 29,846 nCPM
  • mucous neck cells: 20,269 nCPM
  • alveolar cells type 2: 4,261 nCPM
  • foveolar cells: 2,216 nCPM
  • neuroendocrine cells: 523 nCPM

Immune cell

  • intermediate monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 3.2 nTPM
  • white matter: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • amygdala: 0.8 nTPM
  • hippocampal formation: 0.8 nTPM
  • pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGC as an antibody target. Whether an autoantibody or antibody against PGC could matter depends on whether native PGC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGC is annotated as secreted, so native PGC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PGC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...