Seroatlas · Human Serome Atlas

PEX39

Peroxisomal biogenesis factor 39

Also known as: C6orf226, LOC441150, PEX39_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5I0X4
Gene: PEX39
Ensembl: ENSG00000221821
Chromosome: 6
Canonical length: 101 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>Q5I0X4|PEX39
     1  MERPRSPQCS APASASASVT LAQLLQLVQQ GQELPGLEKR HIAAIHGEPT ASRLPRRPKP
    61  WEAAALAESL PPPTLRIGTA PAEPGLVEAA TAPSSWHTVG P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 30 nTPM
hypothalamus: 26 nTPM
skin: 25 nTPM
pituitary gland: 25 nTPM
basal ganglia: 23 nTPM
amygdala: 23 nTPM

Single-cell type

platelets: 85 nCPM
epididymal principal cells: 69 nCPM
respiratory ciliated cells: 43 nCPM
melanocytes: 42 nCPM
fallopian tube ciliated cells: 41 nCPM
megakaryocytes: 37 nCPM

Immune cell

myeloid DC: 26 nTPM
non-classical monocyte: 25 nTPM
NK-cell: 24 nTPM
plasmacytoid DC: 24 nTPM
memory CD4 T-cell: 22 nTPM
classical monocyte: 22 nTPM

Brain region

hypothalamus: 20 nTPM
spinal cord: 19 nTPM
white matter: 19 nTPM
thalamus: 19 nTPM
medulla oblongata: 18 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.3
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

peroxisome

Protein domainsUniProt · Pfam · InterPro

Peroxisomal biogenesis factor 39
Peroxisomal membrane protein PEX14-like, KPWE domain
PEX14-like KPWE domain

KeywordsUniProt

Peroxisome

InteractionsUniProt · HPA

Protein binding partners of PEX39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HNRNPK

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX39 as an antibody target. Whether an autoantibody or antibody against PEX39 could matter depends on whether native PEX39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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