Seroatlas · Human Serome Atlas

PEX13

Peroxisomal membrane protein PEX13

Also known as: PEX13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92968
Gene
PEX13
Ensembl
ENSG00000162928
Chromosome
2
Canonical length
403 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Peroxisomes

OverviewNCBI Gene

This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q92968|PEX13
     1  MASQPPPPPK PWETRRIPGA GPGPGPGPTF QSADLGPTLM TRPGQPALTR VPPPILPRPS
    61  QQTGSSSVNT FRPAYSSFSS GYGAYGNSFY GGYSPYSYGY NGLGYNRLRV DDLPPSRFVQ
   121  QAEESSRGAF QSIESIVHAF ASVSMMMDAT FSAVYNSFRA VLDVANHFSR LKIHFTKVFS
   181  AFALVRTIRY LYRRLQRMLG LRRGSENEDL WAESEGTVAC LGAEDRAATS AKSWPIFLFF
   241  AVILGGPYLI WKLLSTHSDE VTDSINWASG EDDHVVARAE YDFAAVSEEE ISFRAGDMLN
   301  LALKEQQPKV RGWLLASLDG QTTGLIPANY VKILGKRKGR KTVESSKVSK QQQSFTNPTL
   361  TKGATVADSL DEQEAAFESV FVETNKVPVA PDSIGKDGEK QDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • liver: 23 nTPM
  • skeletal muscle: 14 nTPM
  • testis: 14 nTPM
  • prostate: 14 nTPM
  • urinary bladder: 13 nTPM
  • thyroid gland: 13 nTPM

Single-cell type

  • urothelial cells: 186 nCPM
  • late primary spermatocytes: 162 nCPM
  • early spermatids: 110 nCPM
  • esophageal apical cells: 104 nCPM
  • syncytiotrophoblasts: 100 nCPM
  • myonuclei: 91 nCPM

Immune cell

  • basophil: 13 nTPM
  • naive CD4 T-cell: 6.1 nTPM
  • eosinophil: 5.9 nTPM
  • memory CD4 T-cell: 5.8 nTPM
  • memory B-cell: 5.5 nTPM
  • memory CD8 T-cell: 5.5 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • cerebellum: 20 nTPM
  • white matter: 15 nTPM
  • hypothalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • midbrain: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEX13.

Disease | AllUniProt

Conditions PEX13 is implicated in, by any mechanism.

  • Peroxisome biogenesis disorder complementation group 13 (PBD-CG13) MIM:614883
  • Peroxisome biogenesis disorder 11A (PBD11A) MIM:614883
  • Peroxisome biogenesis disorder 11B (PBD11B) MIM:614885

Disease | GeneticClinVar

45 pathogenic / likely-pathogenic of 616 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-0.3
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX13 as an antibody target. Whether an autoantibody or antibody against PEX13 could matter depends on whether native PEX13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEX13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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