Seroatlas · Human Serome Atlas

PEBP4

Phosphatidylethanolamine-binding protein 4

Also known as: CORK1, hPEBP4, MGC22776, PEBP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S96
Gene: PEBP4
Ensembl: ENSG00000134020
Chromosome: 8
Canonical length: 227 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q96S96|PEBP4
     1  MGWTMRLVTA ALLLGLMMVV TGDEDENSPC AHEALLDEDT LFCQGLEVFY PELGNIGCKV
    61  VPDCNNYRQK ITSWMEPIVK FPGAVDGATY ILVMVDPDAP SRAEPRQRFW RHWLVTDIKG
   121  ADLKKGKIQG QELSAYQAPS PPAHSGFHRY QFFVYLQEGK VISLLPKENK TRGSWKMDRF
   181  LNRFHLGEPE ASTQFMTQNY QDSPTLQAPR ERASEPKHKN QAEIAAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 629 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 629 nTPM
tongue: 542 nTPM
epididymis: 361 nTPM
heart muscle: 189 nTPM
lung: 108 nTPM
parathyroid gland: 77 nTPM

Single-cell type

myonuclei: 1,086 nCPM
epididymal principal cells: 968 nCPM
alveolar cells type 2: 857 nCPM
transitional alveolar cells: 435 nCPM
alveolar cells type 1: 302 nCPM
müller glia: 269 nCPM

Immune cell

NK-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
neutrophil: 0.7 nTPM
naive B-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

thalamus: 54 nTPM
cerebellum: 35 nTPM
medulla oblongata: 34 nTPM
midbrain: 33 nTPM
choroid plexus: 31 nTPM
basal ganglia: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEBP4.

Disease | ImmuneIEDB

Conditions an epitope on PEBP4 was assayed in.

breast cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEBP4 as an antibody target. Whether an autoantibody or antibody against PEBP4 could matter depends on whether native PEBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEBP4 is annotated as secreted, so native PEBP4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PEBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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