Seroatlas · Human Serome Atlas

PDPK2P

Putative 3-phosphoinositide-dependent protein kinase 2

Also known as: PDPK2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6A1A2
Gene: PDPK2P
Canonical length: 396 aa

OverviewNCBI Gene

No narrative summary is available for PDPK2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q6A1A2|PDPK2P
     1  MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK RPEDFKFGKI
    61  LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV TRERDVMSRL DHPFFVKLYF
   121  TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF DETCTRFYTA EIVSALEYLH GKGIIHRDLK
   181  PENILLNEDM YIQITDFGTA KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA
   241  LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC
   301  EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNVS WPGWRARQVA
   361  LGPPCTGLHA RAPDPRVICS RKGRVSVPLR QACWWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDPK2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDPK2P as an antibody target. Whether an autoantibody or antibody against PDPK2P could matter depends on whether native PDPK2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDPK2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDPK2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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