Seroatlas · Human Serome Atlas

PDLIM2

PDZ and LIM domain protein 2

Also known as: PDLI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JY6
Gene
PDLIM2
Ensembl
ENSG00000120913
Chromosome
8
Canonical length
352 aa
Protein class
Predicted intracellular proteins
Subcellular location
Actin filaments,Focal adhesion sites

OverviewNCBI Gene

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q96JY6|PDLIM2
     1  MALTVDVAGP APWGFRITGG RDFHTPIMVT KVAERGKAKD ADLRPGDIIV AINGESAEGM
    61  LHAEAQSKIR QSPSPLRLQL DRSQATSPGQ TNGDSSLEVL ATRFQGSVRT YTESQSSLRS
   121  SYSSPTSLSP RAGSPFSPPP SSSSLTGEAA ISRSFQSLAC SPGLPAADRL SYSGRPGSRQ
   181  AGLGRAGDSA VLVLPPSPGP RSSRPSMDSE GGSLLLDEDS EVFKMLQENR EGRAAPRQSS
   241  SFRLLQEALE AEERGGTPAF LPSSLSPQSS LPASRALATP PKLHTCEKCS TSIANQAVRI
   301  QEGRYRHPGC YTCADCGLNL KMRGHFWVGD ELYCEKHARQ RYSAPATLSS RA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
224 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 224 nTPM
  • skeletal muscle: 190 nTPM
  • skin: 147 nTPM
  • blood vessel: 133 nTPM
  • esophagus: 123 nTPM
  • cerebellum: 90 nTPM

Single-cell type

  • enterocytes: 19 nCPM
  • bergmann glia: 17 nCPM
  • brain excitatory neurons: 13 nCPM
  • alveolar cells type 1: 12 nCPM
  • podocytes: 12 nCPM
  • other brain neurons: 8.8 nCPM

Immune cell

  • eosinophil: 159 nTPM
  • neutrophil: 99 nTPM
  • basophil: 76 nTPM
  • non-classical monocyte: 61 nTPM
  • intermediate monocyte: 60 nTPM
  • memory CD8 T-cell: 47 nTPM

Brain region

  • pons: 76 nTPM
  • white matter: 65 nTPM
  • midbrain: 64 nTPM
  • medulla oblongata: 62 nTPM
  • cerebellum: 58 nTPM
  • thalamus: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDLIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDLIM2 as an antibody target. Whether an autoantibody or antibody against PDLIM2 could matter depends on whether native PDLIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDLIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDLIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDLIM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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