Seroatlas · Human Serome Atlas

PDE7B

3',5'-cyclic-AMP phosphodiesterase 7B

Also known as: PDE7B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP56
Gene
PDE7B
Ensembl
ENSG00000171408
Chromosome
6
Canonical length
450 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9NP56|PDE7B
     1  MSCLMVERCG EILFENPDQN AKCVCMLGDI RLRGQTGVRA ERRGSYPFID FRLLNSTTYS
    61  GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED YLGQARHMLS KVGMWDFDIF
   121  LFDRLTNGNS LVTLLCHLFN THGLIHHFKL DMVTLHRFLV MVQEDYHSQN PYHNAVHAAD
   181  VTQAMHCYLK EPKLASFLTP LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS
   241  VLENHHWRST IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN
   301  KDLRLEDAQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGE LEQKFELEIS
   361  PLCNQQKDSI PSIQIGFMSY IVEPLFREWA HFTGNSTLSE NMLGHLAHNK AQWKSLLPRQ
   421  HRSRGSSGSG PDHDHAGQGT ESEEQEGDSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 15 nTPM
  • ovary: 11 nTPM
  • seminal vesicle: 9.7 nTPM
  • tongue: 8.3 nTPM
  • endometrium: 7.3 nTPM
  • smooth muscle: 7.1 nTPM

Single-cell type

  • pituicytes/fscs: 2,708 nCPM
  • podocytes: 907 nCPM
  • renal collecting duct principal cells: 673 nCPM
  • myosatellite cells: 631 nCPM
  • medullary thymic epithelial cells: 547 nCPM
  • astrocytes: 539 nCPM

Immune cell

  • naive B-cell: 1.3 nTPM
  • myeloid DC: 0.8 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • memory B-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM

Brain region

  • basal ganglia: 55 nTPM
  • hypothalamus: 43 nTPM
  • midbrain: 34 nTPM
  • thalamus: 30 nTPM
  • amygdala: 23 nTPM
  • medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.55
gnomAD missense Z
1.37
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDE7B as an antibody target. Whether an autoantibody or antibody against PDE7B could matter depends on whether native PDE7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDE7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDE7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDE7B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...