PDE4B

Protein identityUniProt · HPA

UniProt accession

Q07343

Gene

PDE4B

Ensembl

ENSG00000184588

Chromosome

1

Canonical length

736 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Primary cilium,Cytosol

OverviewNCBI Gene

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>Q07343|PDE4B
     1  MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL QLPPLSQRQS
    61  ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG PSPGRSPLDP QASSSAGLVL
   121  HATFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRSVR
   181  NNFTILTNLH GTSNKRSPAA SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR
   241  SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK
   301  KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH
   361  NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV
   421  LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL
   481  AVGFKLLQEE HCDIFMNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS
   541  SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI
   601  SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP
   661  SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS YFSSTKTLCV IDPENRDSLG
   721  ETDIDIATED KSPVDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

71 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.4

gnomAD pLI

0.47

gnomAD missense Z

2.77

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cAMP catabolic process
• cellular response to epinephrine stimulus
• cellular response to lipopolysaccharide
• cellular response to xenobiotic stimulus
• leukocyte migration
• negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
• negative regulation of cAMP/PKA signal transduction
• negative regulation of relaxation of cardiac muscle
• neutrophil chemotaxis
• neutrophil homeostasis
• positive regulation of interleukin-2 production
• positive regulation of type II interferon production
• regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
• regulation of cardiac muscle cell contraction
• T cell receptor signaling pathway

Molecular functions

• 3',5'-cyclic-AMP phosphodiesterase activity
• 3',5'-cyclic-GMP phosphodiesterase activity
• calcium channel regulator activity
• cAMP binding
• gamma-tubulin binding
• metal ion binding
• transmembrane transporter binding

Cellular components

• centrosome
• cytosol
• dendritic spine
• excitatory synapse
• gamma-tubulin complex
• postsynaptic density
• synaptic vesicle
• voltage-gated calcium channel complex
• Z disc

Protein domainsUniProt · Pfam · InterPro

• 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
• HD/PDEase domain
• 3'5'-cyclic nucleotide phosphodiesterase
• 3'5'-cyclic nucleotide phosphodiesterase, conserved site
• 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
• Phosphodiesterase 4 upstream conserved regions (UCR)
• 3'5'-cyclic nucleotide phosphodiesterase
• Phosphodiesterase 4 upstream conserved regions (UCR)

KeywordsUniProt

• cAMP
• Cell membrane
• Cytoplasm
• Hydrolase
• Membrane
• Metal-binding
• Phosphoprotein
• Zinc

InteractionsUniProt · HPA

Protein binding partners of PDE4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DISC1