Seroatlas · Human Serome Atlas

PDE2A

cGMP-dependent 3',5'-cyclic phosphodiesterase

Also known as: PDE2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00408
Gene
PDE2A
Ensembl
ENSG00000186642
Chromosome
11
Canonical length
941 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of signal transduction; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>O00408|PDE2A
     1  MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
    61  SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
   121  GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
   181  EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
   241  DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
   301  EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
   361  EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
   421  ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
   481  AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
   541  SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
   601  ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
   661  AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
   721  SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
   781  QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
   841  GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
   901  KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
188 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 188 nTPM
  • cerebral cortex: 120 nTPM
  • adipose tissue: 85 nTPM
  • breast: 82 nTPM
  • amygdala: 78 nTPM
  • basal ganglia: 74 nTPM

Single-cell type

  • lymphatic endothelial cells: 120 nCPM
  • neutrophils: 114 nCPM
  • tuft cells: 104 nCPM
  • vascular endothelial cells: 98 nCPM
  • brain inhibitory neurons: 74 nCPM
  • adrenal medulla cells: 64 nCPM

Immune cell

  • gdT-cell: 7.3 nTPM
  • memory CD4 T-cell: 4.4 nTPM
  • memory CD8 T-cell: 4.3 nTPM
  • MAIT T-cell: 4.2 nTPM
  • memory B-cell: 2.8 nTPM
  • naive CD4 T-cell: 2.7 nTPM

Brain region

  • cerebral cortex: 258 nTPM
  • amygdala: 204 nTPM
  • basal ganglia: 191 nTPM
  • hippocampal formation: 166 nTPM
  • white matter: 145 nTPM
  • hypothalamus: 86 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDE2A.

Disease | AllUniProt

Conditions PDE2A is implicated in, by any mechanism.

  • Intellectual developmental disorder with paroxysmal dyskinesia or seizures (IDDPADS) MIM:619150

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 379 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.63
gnomAD missense Z
4.06
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDE2A as an antibody target. Whether an autoantibody or antibody against PDE2A could matter depends on whether native PDE2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDE2A is annotated at the cell surface, where native PDE2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDE2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDE2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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