Seroatlas · Human Serome Atlas

PDCL2

Phosducin-like protein 2

Also known as: GCPHLP, PDCL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4E4
Gene: PDCL2
Ensembl: ENSG00000163440
Chromosome: 4
Canonical length: 241 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Centrosome

OverviewNCBI Gene

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q8N4E4|PDCL2
     1  MQDPNEDTEW NDILRDFGIL PPKEESKDEI EEMVLRLQKE AMVKPFEKMT LAQLKEAEDE
    61  FDEEDMQAVE TYRKKRLQEW KALKKKQKFG ELREISGNQY VNEVTNAEED VWVIIHLYRS
   121  SIPMCLLVNQ HLSLLARKFP ETKFVKAIVN SCIQHYHDNC LPTIFVYKNG QIEAKFIGII
   181  ECGGINLKLE ELEWKLAEVG AIQTDLEENP RKDMVDMMVS SIRNTSIHDD SDSSNSDNDT
   241  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

testis: 62 nTPM
esophagus: 0.3 nTPM
skin: 0.2 nTPM
pituitary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early spermatids: 1,630 nCPM
late spermatids: 904 nCPM
late primary spermatocytes: 530 nCPM
differentiating spermatogonia: 59 nCPM
early primary spermatocytes: 54 nCPM
undifferentiated spermatogonia: 16 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.3 nTPM
thalamus: 0.3 nTPM
cerebral cortex: 0.2 nTPM
spinal cord: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDCL2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 24 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCL2 as an antibody target. Whether an autoantibody or antibody against PDCL2 could matter depends on whether native PDCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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