Seroatlas · Human Serome Atlas

PDCD11

Protein RRP5 homolog

Also known as: ALG-4, KIAA0185, NFBP, RRP5, RRP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14690
Gene
PDCD11
Ensembl
ENSG00000148843
Chromosome
10
Canonical length
1871 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli rim,Vesicles

OverviewNCBI Gene

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

1871 residues, UniProt reviewed canonical sequence.

>Q14690|PDCD11
     1  MANLEESFPR GGTRKIHKPE KAFQQSVEQD NLFDISTEEG STKRKKSQKG PAKTKKLKIE
    61  KRESSKSARE KFEILSVESL CEGMRILGCV KEVNELELVI SLPNGLQGFV QVTEICDAYT
   121  KKLNEQVTQE QPLKDLLHLP ELFSPGMLVR CVVSSLGITD RGKKSVKLSL NPKNVNRVLS
   181  AEALKPGMLL TGTVSSLEDH GYLVDIGVDG TRAFLPLLKA QEYIRQKNKG AKLKVGQYLN
   241  CIVEKVKGNG GVVSLSVGHS EVSTAIATEQ QSWNLNNLLP GLVVKAQVQK VTPFGLTLNF
   301  LTFFTGVVDF MHLDPKKAGT YFSNQAVRAC ILCVHPRTRV VHLSLRPIFL QPGRPLTRLS
   361  CQNLGAVLDD VPVQGFFKKA GATFRLKDGV LAYARLSHLS DSKNVFNPEA FKPGNTHKCR
   421  IIDYSQMDEL ALLSLRTSII EAQYLRYHDI EPGAVVKGTV LTIKSYGMLV KVGEQMRGLV
   481  PPMHLADILM KNPEKKYHIG DEVKCRVLLC DPEAKKLMMT LKKTLIESKL PVITCYADAK
   541  PGLQTHGFII RVKDYGCIVK FYNNVQGLVP KHELSTEYIP DPERVFYTGQ VVKVVVLNCE
   601  PSKERMLLSF KLSSDPEPKK EPAGHSQKKG KAINIGQLVD VKVLEKTKDG LEVAVLPHNI
   661  RAFLPTSHLS DHVANGPLLH HWLQAGDILH RVLCLSQSEG RVLLCRKPAL VSTVEGGQDP
   721  KNFSEIHPGM LLIGFVKSIK DYGVFIQFPS GLSGLAPKAI MSDKFVTSTS DHFVEGQTVA
   781  AKVTNVDEEK QRMLLSLRLS DCGLGDLAIT SLLLLNQCLE ELQGVRSLMS NRDSVLIQTL
   841  AEMTPGMFLD LVVQEVLEDG SVVFSGGPVP DLVLKASRYH RAGQEVESGQ KKKVVILNVD
   901  LLKLEVHVSL HQDLVNRKAR KLRKGSEHQA IVQHLEKSFA IASLVETGHL AAFSLTSHLN
   961  DTFRFDSEKL QVGQGVSLTL KTTEPGVTGL LLAVEGPAAK RTMRPTQKDS ETVDEDEEVD
  1021  PALTVGTIKK HTLSIGDMVT GTVKSIKPTH VVVTLEDGII GCIHASHILD DVPEGTSPTT
  1081  KLKVGKTVTA RVIGGRDMKT FKYLPISHPR FVRTIPELSV RPSELEDGHT ALNTHSVSPM
  1141  EKIKQYQAGQ TVTCFLKKYN VVKKWLEVEI APDIRGRIPL LLTSLSFKVL KHPDKKFRVG
  1201  QALRATVVGP DSSKTLLCLS LTGPHKLEEG EVAMGRVVKV TPNEGLTVSF PFGKIGTVSI
  1261  FHMSDSYSET PLEDFVPQKV VRCYILSTAD NVLTLSLRSS RTNPETKSKV EDPEINSIQD
  1321  IKEGQLLRGY VGSIQPHGVF FRLGPSVVGL ARYSHVSQHS PSKKALYNKH LPEGKLLTAR
  1381  VLRLNHQKNL VELSFLPGDT GKPDVLSASL EGQLTKQEER KTEAEERDQK GEKKNQKRNE
  1441  KKNQKGQEEV EMPSKEKQQP QKPQAQKRGG RECRESGSEQ ERVSKKPKKA GLSEEDDSLV
  1501  DVYYREGKEE AEETNVLPKE KQTKPAEAPR LQLSSGFAWN VGLDSLTPAL PPLAESSDSE
  1561  EDEKPHQATI KKSKKERELE KQKAEKELSR IEEALMDPGR QPESADDFDR LVLSSPNSSI
  1621  LWLQYMAFHL QATEIEKARA VAERALKTIS FREEQEKLNV WVALLNLENM YGSQESLTKV
  1681  FERAVQYNEP LKVFLHLADI YAKSEKFQEA GELYNRMLKR FRQEKAVWIK YGAFLLRRSQ
  1741  AAASHRVLQR ALECLPSKEH VDVIAKFAQL EFQLGDAERA KAIFENTLST YPKRTDVWSV
  1801  YIDMTIKHGS QKDVRDIFER VIHLSLAPKR MKFFFKRYLD YEKQHGTEKD VQAVKAKALE
  1861  YVEAKSSVLE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 15 nTPM
  • skin: 15 nTPM
  • testis: 14 nTPM
  • esophagus: 11 nTPM
  • pancreas: 11 nTPM
  • thymus: 11 nTPM

Single-cell type

  • early spermatids: 77 nCPM
  • erythrocyte progenitors: 67 nCPM
  • megakaryocyte-erythroid progenitors: 56 nCPM
  • late primary spermatocytes: 50 nCPM
  • undifferentiated spermatogonia: 49 nCPM
  • sertoli cells: 46 nCPM

Immune cell

  • MAIT T-cell: 5.2 nTPM
  • memory B-cell: 3.4 nTPM
  • plasmacytoid DC: 3.3 nTPM
  • gdT-cell: 3.2 nTPM
  • naive CD8 T-cell: 3.2 nTPM
  • memory CD4 T-cell: 3.1 nTPM

Brain region

  • thalamus: 13 nTPM
  • basal ganglia: 12 nTPM
  • hypothalamus: 12 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 11 nTPM
  • choroid plexus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
-1.24
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD11 as an antibody target. Whether an autoantibody or antibody against PDCD11 could matter depends on whether native PDCD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDCD11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...