PDC

Protein identityUniProt · HPA

UniProt accession

P20941

Gene

PDC

Ensembl

ENSG00000116703

Chromosome

1

Canonical length

246 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>P20941|PDC
     1  MEEAKSQSLE EDFEGQATHT GPKGVINDWR KFKLESQDSD SIPPSKKEIL RQMSSPQSRN
    61  GKDSKERVSR KMSIQEYELI HKEKEDENCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG
   121  KQFLETIEKE LKITTIVVHI YEDGIKGCDA LNSSLTCLAA EYPIVKFCKI KASNTGAGDR
   181  FSLDVLPTLL IYKGGELISN FISVAEQFAE EFFAGDVESF LNEYGLLPER EVHVLEHTKI
   241  EEEDVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

619 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDC.

Disease | AutoantibodyPubMed

Conditions in which antibodies against PDC are reported. Each links to that disease's full target list.

• Liver Cirrhosis, Biliary 11

ReferencesPubMed · IEDB

Publications for PDC from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.42

gnomAD pLI

0

gnomAD missense Z

0.6

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• phototransduction
• regulation of G protein-coupled receptor signaling pathway
• visual perception

Molecular functions

• phospholipase inhibitor activity

Cellular components

• cytosol
• nucleus
• photoreceptor inner segment
• photoreceptor outer segment

Protein domainsUniProt · Pfam · InterPro

• Phosducin
• Phosducin, N-terminal domain superfamily
• Phosducin, thioredoxin-like domain
• Thioredoxin-like superfamily
• Phosducin-like regulator
• Phosducin

KeywordsUniProt

• Cell projection
• Cilium
• Cytoplasm
• Nucleus
• Phosphoprotein
• Sensory transduction
• Vision

InteractionsUniProt · HPA

Protein binding partners of PDC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CRX