Seroatlas · Human Serome Atlas

PCTP

Phosphatidylcholine transfer protein

Also known as: PPCT_HUMAN, STARD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKL6
Gene: PCTP
Ensembl: ENSG00000141179
Chromosome: 17
Canonical length: 214 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in phospholipid transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q9UKL6|PCTP
     1  MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG LYEYKVFGVL
    61  EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY WEVKYPFPMS NRDYVYLRQR
   121  RDLDMEGRKI HVILARSTSM PQLGERSGVI RVKQYKQSLA IESDGKKGSK VFMYYFDNPG
   181  GQIPSWLINW AAKNGVPNFL KDMARACQNY LKKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCTP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

liver: 92 nTPM
kidney: 28 nTPM
placenta: 27 nTPM
epididymis: 27 nTPM
rectum: 22 nTPM
seminal vesicle: 22 nTPM

Single-cell type

platelets: 104 nCPM
hepatocytes: 101 nCPM
extravillous trophoblasts: 94 nCPM
syncytiotrophoblasts: 85 nCPM
neutrophils: 74 nCPM
cytotrophoblasts: 67 nCPM

Immune cell

eosinophil: 242 nTPM
basophil: 78 nTPM
neutrophil: 64 nTPM
classical monocyte: 61 nTPM
non-classical monocyte: 59 nTPM
intermediate monocyte: 53 nTPM

Brain region

thalamus: 11 nTPM
midbrain: 10 nTPM
hypothalamus: 9.3 nTPM
medulla oblongata: 8 nTPM
pons: 8 nTPM
choroid plexus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCTP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACOT13

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCTP as an antibody target. Whether an autoantibody or antibody against PCTP could matter depends on whether native PCTP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCTP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCTP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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