Seroatlas · Human Serome Atlas

ACOT13

Acyl-coenzyme A thioesterase 13

Also known as: ACO13_HUMAN, HT012, THEM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPJ3
Gene
ACOT13
Ensembl
ENSG00000112304
Chromosome
6
Canonical length
140 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cell Junctions
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q9NPJ3|ACOT13
     1  MTSMTQSLRE VIKAMTKARN FERVLGKITL VSAAPGKVIC EMKVEEEHTN AIGTLHGGLT
    61  ATLVDNISTM ALLCTERGAP GVSVDMNITY MSPAKLGEDI VITAHVLKQG KTLAFTSVDL
   121  TNKATGKLIA QGRHTKHLGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • liver: 29 nTPM
  • kidney: 18 nTPM
  • skeletal muscle: 12 nTPM
  • heart muscle: 11 nTPM
  • tongue: 9.6 nTPM
  • midbrain: 8.8 nTPM

Single-cell type

  • early spermatids: 1,134 nCPM
  • late primary spermatocytes: 449 nCPM
  • hepatocytes: 233 nCPM
  • epicardial cells: 182 nCPM
  • late spermatids: 142 nCPM
  • colonocytes: 114 nCPM

Immune cell

  • memory B-cell: 7 nTPM
  • neutrophil: 6.2 nTPM
  • MAIT T-cell: 6.1 nTPM
  • non-classical monocyte: 5.8 nTPM
  • intermediate monocyte: 5.7 nTPM
  • naive CD4 T-cell: 5.7 nTPM

Brain region

  • thalamus: 14 nTPM
  • midbrain: 14 nTPM
  • cerebellum: 14 nTPM
  • hypothalamus: 14 nTPM
  • pons: 13 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACOT13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT13 as an antibody target. Whether an autoantibody or antibody against ACOT13 could matter depends on whether native ACOT13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACOT13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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