PCDHGC3

Protein identityUniProt · HPA

UniProt accession

Q9UN70

Gene

PCDHGC3

Ensembl

ENSG00000240184

Chromosome

5

Canonical length

934 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

934 residues, UniProt reviewed canonical sequence.

>Q9UN70|PCDHGC3
     1  MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV VANLGLDLGS
    61  LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT LPSCTVTLEL VVENPLELFS
   121  VEVVIQDIND NNPAFPTQEM KLEISEAVAP GTRFPLESAH DPDVGSNSLQ TYELSRNEYF
   181  ALRVQTREDS TKYAELVLER ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN
   241  APVFNQSLYR ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV
   301  TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP EITVTSVYSP
   361  VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT SSLKNYFTLK TSADLDRETV
   421  PEYNLSITAR DAGTPSLSAL TIVRVQVSDI NDNPPQSSQS SYDVYIEENN LPGAPILNLS
   481  VWDPDAPQNA RLSFFLLEQG AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS
   541  DGGTPVLATN ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA
   601  GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD NGEPSLSTTA
   661  TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL VSVGFVVTVF GVIIFKVYKW
   721  KQSRDLYRAP VSSLYRTPGP SLHADAVRGG LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS
   781  PLASRQNTLR SCDPVFYRQV LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW
   841  PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP
   901  GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHGC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

360 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.13

gnomAD missense Z

1.41

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
• cell adhesion
• homophilic cell adhesion via plasma membrane adhesion molecules
• negative regulation of neuron apoptotic process
• nervous system development
• synapse organization

Molecular functions

• calcium ion binding
• cell adhesion molecule binding

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Cadherin-like
• Cadherin, N-terminal
• Cadherin-like superfamily
• Cadherin conserved site
• Cadherin, C-terminal catenin-binding domain
• Cadherin, cytoplasmic C-terminal domain
• Protocadherin/Cadherin-related Cell Adhesion
• Cadherin domain
• Cadherin-like
• Cadherin C-terminal cytoplasmic tail, catenin-binding region
• Cadherin cytoplasmic C-terminal

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell membrane
• Glycoprotein
• Membrane
• Repeat
• Signal
• Transmembrane
• Transmembrane helix