Seroatlas · Human Serome Atlas

PCDHGA8

Protocadherin gamma-A8

Also known as: KIAA0327, PCDG8_HUMAN, PCDH-GAMMA-A8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5G5
Gene: PCDHGA8
Ensembl: ENSG00000253767
Chromosome: 5
Canonical length: 932 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

932 residues, UniProt reviewed canonical sequence.

>Q9Y5G5|PCDHGA8
     1  MAAPQSRPRR GELILLCALL GTLWEIGRGQ IRYSVPEETD KGSFVGNISK DLGLDPRKLA
    61  KHGVRIVSRG RTQLFALNPR SGSLITAGRI DREELCAQSP RCLININTLV EDKGKLFGVE
   121  IEIIDINDNN PKFQVEDLEV KINEIAVPGA RYPLPEAVDP DVGVNSLQSY QLSPNHHFSL
   181  DVQTGDNGAI NPELVLERAL DREEEAAHHL VLTASDGGKP PRSSTVRIHV TVLDTNDNAP
   241  VFPHPIYRVK VLENMPPGTR LLTVTASDPD EGINGKVAYK FRKINEKQTP LFQLNENTGE
   301  ISIAKSLDYE ECSFYEMEIQ AEDVGALLGR TKLLISVEDV NDNRPEVIIT SLFSPVLENS
   361  LPGTVIAFLS VHDQDSGKNG QVVCYTRDNL PFKLEKSIGN YYRLVTRKYL DRENVSIYNI
   421  TVMASDLGTP PLSTETQIAL HVADINDNPP TFPHASYSAY ILENNLRGAS IFSLTAHDPD
   481  SQENAQVTYS VTEDTLQGAP LSSYISINSD TGVLYALQSF DYEQIRDLQL LVTASDSGDP
   541  PLSSNMSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAERGYLVTK VVAVDRDSGQ
   601  NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL
   661  TVAVADSIPE VLTELGSLKP SVDPNDSSLT LYLVVAVAAI SCVFLAFVAV LLGLRLRRWH
   721  KSRLLQDSGG RLVGVPASHF VGVEEVQAFL QTYSQEVSLT ADSRKSHLIF PQPNYADMLI
   781  SQEGCEKNDS LLTSVDFHEY KNEADHGQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN
   841  NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
   901  NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHGA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 0.4 nTPM
retina: 0.4 nTPM
ovary: 0.3 nTPM
skin: 0.3 nTPM
thyroid gland: 0.3 nTPM
blood vessel: 0.2 nTPM

Single-cell type

cardiomyocytes: 0.1 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM
hepatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.3 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 12 nTPM
medulla oblongata: 6.4 nTPM
white matter: 6.3 nTPM
thalamus: 6.1 nTPM
cerebral cortex: 5.9 nTPM
midbrain: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHGA8 as an antibody target. Whether an autoantibody or antibody against PCDHGA8 could matter depends on whether native PCDHGA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHGA8 is annotated at the cell surface, where native PCDHGA8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHGA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...