PCDHGA11

Protein identityUniProt · HPA

UniProt accession

Q9Y5H2

Gene

PCDHGA11

Ensembl

ENSG00000253873

Chromosome

5

Canonical length

935 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Vesicles,Plasma membrane,Cytosol

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

935 residues, UniProt reviewed canonical sequence.

>Q9Y5H2|PCDHGA11
     1  MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS KDLGLEPREL
    61  AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV SSCFLNMELL VEDTLKIYGV
   121  EVEIIDINDN APSFQEDEVE IKVSEHAIPG ARFALPNARD PDVGVNSLQS YQLSPNNYFS
   181  LQLRGRTDGA KNPELVLEGS LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI
   241  PMFTQSVYRV SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG
   301  EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI TSSINSILEN
   361  SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG NYYKLITSRV LDRELVQSYN
   421  ITLTATDQGS PPLSAETHVW LNVADDNDNP PVFPHSSYSA YIPENNPRGA SIFSVTALDP
   481  DSKQNALVTY SLTDDTVQGV PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD
   541  PPLSSNVSLS LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG
   601  QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH GQPPLSATVT
   661  LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA VSCIFLVFVI VLLALRLWRW
   721  HKSRLLQASE GGLAGMPTSH FVGVDGVQAF LQTYSHEVSL IADSQKSHLI FPQPNYGDTL
   781  ISQESCEKSE PLLIAEDSAI ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT
   841  WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
   901  PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHGA11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

2.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.91

gnomAD pLI

0

gnomAD missense Z

1.07

DepMap mean gene effect

0.19

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• homophilic cell adhesion via plasma membrane adhesion molecules
• nervous system development

Molecular functions

• calcium ion binding
• cell adhesion molecule binding

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Cadherin-like
• Cadherin, N-terminal
• Cadherin-like superfamily
• Cadherin conserved site
• Cadherin, C-terminal catenin-binding domain
• Cadherin, cytoplasmic C-terminal domain
• Protocadherin/Cadherin-related Cell Adhesion
• Cadherin domain
• Cadherin-like
• Cadherin C-terminal cytoplasmic tail, catenin-binding region
• Cadherin cytoplasmic C-terminal

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell membrane
• Glycoprotein
• Membrane
• Repeat
• Signal
• Transmembrane
• Transmembrane helix