Seroatlas · Human Serome Atlas

PCDHGA10

Protocadherin gamma-A10

Also known as: PCDGA_HUMAN, PCDH-GAMMA-A10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5H3
Gene
PCDHGA10
Ensembl
ENSG00000253846
Chromosome
5
Canonical length
936 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

936 residues, UniProt reviewed canonical sequence.

>Q9Y5H3|PCDHGA10
     1  MAAQRNRSKE SKDCSGLVLL CLFFGIPWEA GARQISYSIP EELEKGSFVG NISKDLGLAP
    61  RELAERGVRI VSRGRTQLFS LNPRSGSLIT AGRIDREELC AQSARCVVSF NILVEDRVKL
   121  FGIEIEVTDI NDNAPKFQAE NLDVKINENV AAGMRFPLPE AIDPDVGVNS LQSYQLSPNK
   181  HFSLRVQSRA NGVKYPELVL EHSLDREEEA IHHLVLTASD GGDPLRSGTV LVSVTVFDAN
   241  DNAPVFTLPE YRVSVPENLP VGTQLLTVTA TDRDEGANGE VTYSFRKLPD TQLLKFQLNK
   301  YTGEIKISEN LDYEETGFYE IEIQAEDGGA YLATAKVLIT VEDVNDNSPE LTITSLFSPV
   361  TEDSPLGTVV ALLNVHDLDS EQNGQVTCSI LAYLPFKLEK SIDSYYRLVI HRALDREQVS
   421  SYNITVTATD GGSPPLSTEA HFMLQVADIN DNPPTFSQVS YFTYIPENNA RGASIFSVTA
   481  LDPDSKENAQ IIYSLAEDTI QGVPLSSYIS INSDTGVLYA LRSFDYEQFH ELQMQVTASD
   541  SGDPPLSSNV SLSLFVLDQN DNAPEILYPA LPTDGSTGVE LAPRSAEPGY LVTKVVAVDR
   601  DSGQNAWLSY RLLKASEPGL FAVGEHTGEV RTARALLDRD ALKQSLVVAV QDHGQPPLSA
   661  TVTLTVAVAD SIPQVLADLG SFESPANSET SDLTLYLVVA VAAVSCVFLA FVIVLLAHRL
   721  RRWHKSRLLQ ASGGGLTGVS GSHFVGVDGV RAFLQTYSHE VSLTADSRKS HLIFPQPNYA
   781  DTLISQESCE KNDPLSLLDD SKFPIEDTPL VPQAPPNTDW RFSQAQRPGT SGSQNGDDTG
   841  TWPNNQFDTE MLQAMILASA SEAADGSSTL GGGAGTMGLS ARYGPQFTLQ HVPDYRQNVY
   901  IPGSNATLTN AAGKRDGKAP AGGNGNKKKS GKKEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHGA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 15 nTPM
  • placenta: 3.4 nTPM
  • basal ganglia: 3.2 nTPM
  • retina: 2.4 nTPM
  • amygdala: 2 nTPM
  • parathyroid gland: 2 nTPM

Single-cell type

  • bergmann glia: 39 nCPM
  • astrocytes: 30 nCPM
  • oligodendrocyte progenitor cells: 25 nCPM
  • brain excitatory neurons: 19 nCPM
  • brain inhibitory neurons: 16 nCPM
  • choroid plexus epithelial cells: 14 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • spinal cord: 17 nTPM
  • cerebellum: 16 nTPM
  • thalamus: 16 nTPM
  • hypothalamus: 16 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
1
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHGA10 as an antibody target. Whether an autoantibody or antibody against PCDHGA10 could matter depends on whether native PCDHGA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHGA10 is annotated at the cell surface, where native PCDHGA10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHGA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCDHGA10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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