Seroatlas · Human Serome Atlas

PCDHB7

Protocadherin beta-7

Also known as: PCDB7_HUMAN, PCDH-BETA7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5E2
Gene: PCDHB7
Ensembl: ENSG00000113212
Chromosome: 5
Canonical length: 793 aa
Protein class: Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

793 residues, UniProt reviewed canonical sequence.

>Q9Y5E2|PCDHB7
     1  MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK DLGLGVGELR
    61  ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE PCVLPFQLLL EKPFQIFRAE
   121  LWVRDINDHA PVFLDREISL KILESTTPGA AFLLESAQDS DVGTNSLSNY TISPNAYFHI
   181  NVHDSGEGNI YPELVLNQVL DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP
   241  DFVRSLYKVQ VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS
   301  LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS SLTSPIAENS
   361  PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF YTLVTEKPLD RERNTEYNIT
   421  ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALPI GSVSATDRDS
   481  GTNAQVIYSL LPSQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA
   541  LSSEALVRVL VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA
   601  WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV
   661  LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL LSVLLFVAVR LCRRSRAAPV
   721  GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE
   781  VEENRPFQNN LGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

endometrium: 4 nTPM
blood vessel: 3.9 nTPM
cervix: 3 nTPM
smooth muscle: 2.9 nTPM
fallopian tube: 2.6 nTPM
pituitary gland: 2.3 nTPM

Single-cell type

late primary spermatocytes: 62 nCPM
early spermatids: 35 nCPM
late spermatids: 33 nCPM
decidual stromal cells: 6.4 nCPM
müller glia: 5.3 nCPM
respiratory ionocytes: 5.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 6.9 nTPM
cerebral cortex: 6.3 nTPM
midbrain: 5.8 nTPM
hippocampal formation: 5.1 nTPM
spinal cord: 5 nTPM
white matter: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -2.66
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHB7 as an antibody target. Whether an autoantibody or antibody against PCDHB7 could matter depends on whether native PCDHB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHB7 is annotated at the cell surface, where native PCDHB7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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