Seroatlas · Human Serome Atlas

PCDHB18P

Putative protocadherin beta-18

Also known as: PCDBI_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96TA0
Gene: PCDHB18P
Canonical length: 734 aa

OverviewNCBI Gene

No narrative summary is available for PCDHB18P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

734 residues, UniProt reviewed canonical sequence.

>Q96TA0|PCDHB18P
     1  MWKTWLQGGA RVIFDDYKPY LRLDPQNGDL LLNEQLDREA LCDLTEPCIL HFQVLFENPL
    61  QFFRAELLVK DINDHTPTFL NNHMLLKISE GATLGTLFQI DSAQDLDVGK NGVQNYTISP
   121  NPHFHLKLRD SDEGRKYPEL VLDQSLDREK VSEFSLTLTA VDGGSPPRSG TTLINVVVLD
   181  ISDNAPEFEK PVYEVLVPES SPLDSLIIKA SATDLDAGIN GELSYSFSHV SRDVRKTFEI
   241  HPISGEVYLK APLDFEIIQS YIINIQAIEG GSLSGKSSIL VRVVDVNDNP PEIAMTSLTS
   301  PIPENSSPEM VVAVFSIRDQ DAGDNGRTVC SIQDNLPFVL KPTFKNFYAL VTEHPLDREV
   361  RNEYNITITV TDLGTPRLKT EHNITVLVSD VNDNAPIFTQ TSYTLFVREN NSPALHIGSV
   421  SATDRDSGTN AQVTYSLLPP QDPHLPLTSL VSINADNGHL FALRSLDYEA LQEFGFRVGA
   481  ADHGSPALSS EVLVRVLVLD ANDNSPFVLY PLQNGSAPCT ELVPRAAEPG YLVTKVVAVD
   541  GDSGQNAWLS YQLLKATEPG LFGVWAHNGE GRTARLLSER DAAKHRLVVL VKDNGEPPRS
   601  ATATLHVLLV EGFSQPYLPL TEAAPSQAQA DSLTVYLVVA LASVSSLFLF SVFLFVAVRL
   661  CRRSRAASMG RCSVPECPFP GHLVDVSGTG TLSQSYQYEV CLTGGSGANE FKFLKPVIPN
   721  LLSRDSEMEK APPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHB18P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHB18P as an antibody target. Whether an autoantibody or antibody against PCDHB18P could matter depends on whether native PCDHB18P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHB18P is annotated at the cell surface, where native PCDHB18P is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHB18P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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