Seroatlas · Human Serome Atlas

PCDHB14

Protocadherin beta-14

Also known as: PCDBE_HUMAN, PCDH-BETA14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5E9
Gene
PCDHB14
Ensembl
ENSG00000120327
Chromosome
5
Canonical length
798 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>Q9Y5E9|PCDHB14
     1  MEIRGALDLR KRQVLIFLVL LGLSRAGTES AHYSVAEETE IGSFVANLAR DLGLGVEELS
    61  SREARVVSDD NKKYLHLDLL TGNLLLNEKL DRDELCGSTE PCVLHFQVVL ENPLQFFRFE
   121  LCVKDINDHS PTFLDKEILI KISEGTTVGA TFLMESAQDL DVGSNSLQNY TISPNSHFYI
   181  KIPDSSDRKI YPELVLDRAL DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP
   241  EFPQSLYEVQ VPEDRPLGSW IATISAKDLD AGNYGKISYT FFHASEDIRK TFEINPISGE
   301  VNLRSPLDFE VIQSYTINIQ ATDGGGLSGK CTLLVKVMDI NDNPPEVTIS SITKRIPENA
   361  SETLVALFSI LDQDSGDNGR MICSIQDNLP FFLKPTFKNF FTLVSEKALD RESQAEYNIT
   421  ITVTDLGTPR LKTEYNITVL LSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS
   481  GTNAQVNYSL LPPQDRHLPL ASLVSINADN GHLFALRSLD YEALQEFEFR VGATDRGSPA
   541  LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
   601  WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV
   661  LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA
   721  SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSG TNEFKFLKPI IPNFQVHDTG
   781  RNMGEIENFR NSFGLNIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 6.7 nTPM
  • endometrium: 6.3 nTPM
  • cerebellum: 6 nTPM
  • cervix: 6 nTPM
  • pituitary gland: 6 nTPM
  • cerebral cortex: 5.2 nTPM

Single-cell type

  • brain inhibitory neurons: 14 nCPM
  • astrocytes: 12 nCPM
  • bergmann glia: 12 nCPM
  • brain excitatory neurons: 12 nCPM
  • ependymal cells: 10 nCPM
  • oligodendrocyte progenitor cells: 9.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 15 nTPM
  • thalamus: 14 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 12 nTPM
  • hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0
gnomAD missense Z
-1.42
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHB14 as an antibody target. Whether an autoantibody or antibody against PCDHB14 could matter depends on whether native PCDHB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHB14 is annotated at the cell surface, where native PCDHB14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCDHB14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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