Seroatlas · Human Serome Atlas

PCDHB10

Protocadherin beta-10

Also known as: PCDBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UN67
Gene: PCDHB10
Ensembl: ENSG00000120324
Chromosome: 5
Canonical length: 800 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

800 residues, UniProt reviewed canonical sequence.

>Q9UN67|PCDHB10
     1  MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK DLGLAEGELA
    61  ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE
   121  LRVRDINDHA PVFQDKETVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI
   181  NISGGDEGMI YPELVLDKAL DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP
   241  QFAQALYETQ APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE
   301  IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS SFSNSVAENS
   361  PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT
   421  ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS
   481  GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA
   541  LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
   601  WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHL
   661  LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR
   721  AASVGRCSVP EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG
   781  PGRKGEENST FRNSFGFNIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDHB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.6 nTPM
blood vessel: 4.3 nTPM
pituitary gland: 3.4 nTPM
basal ganglia: 3.1 nTPM
spinal cord: 3 nTPM
endometrium: 2.9 nTPM

Single-cell type

corticotrophs: 13 nCPM
lactotrophs: 6.6 nCPM
hepatic stellate cells: 6.5 nCPM
retinal bipolar cells: 5.6 nCPM
brain inhibitory neurons: 5.2 nCPM
decidual stromal cells: 4.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 9.8 nTPM
thalamus: 9.8 nTPM
midbrain: 9.6 nTPM
hippocampal formation: 9.3 nTPM
amygdala: 8.9 nTPM
white matter: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -2.39
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDHB10 as an antibody target. Whether an autoantibody or antibody against PCDHB10 could matter depends on whether native PCDHB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDHB10 is annotated at the cell surface, where native PCDHB10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDHB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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