Seroatlas · Human Serome Atlas

PCDH18

Protocadherin-18

Also known as: KIAA1562, PCD18_HUMAN, PCDH68L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCL0
Gene: PCDH18
Ensembl: ENSG00000189184
Chromosome: 4
Canonical length: 1135 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1135 residues, UniProt reviewed canonical sequence.

>Q9HCL0|PCDH18
     1  MHQMNAKMHF RFVFALLIVS FNHDVLGKNL KYRIYEEQRV GSVIARLSED VADVLLKLPN
    61  PSTVRFRAMQ RGNSPLLVVN EDNGEISIGA TIDREQLCQK NLNCSIEFDV ITLPTEHLQL
   121  FHIEVEVLDI NDNSPQFSRS LIPIEISESA AVGTRIPLDS AFDPDVGENS LHTYSLSAND
   181  FFNIEVRTRT DGAKYAELIV VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN
   241  DNSPAFEQQS YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIMETFKID
   301  SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN KPEININLMS
   361  PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH GHGHFKLQKT YENNYLILTN
   421  ATLDREKRSE YSLTVIAEDR GTPSLSTVKH FTVQINDIND NPPHFQRSRY EFVISENNSP
   481  GAYITTVTAT DPDLGENGQV TYTILESFIL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ
   541  ITFVVEARDG GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEITI PKGAESGFHV
   601  TRIRAIDRDS GVNAELSCAI VAGNEENIFI IDPRSCDIHT NVSMDSVPYT EWELSVIIQD
   661  KGNPQLHTKV LLKCMIFEYA ESVTSTAMTS VSQASLDVSM IIIISLGAIC AVLLVIMVLF
   721  ATRCNREKKD TRSYNCRVAE STYQHHPKRP SRQIHKGDIT LVPTINGTLP IRSHHRSSPS
   781  SSPTLERGQM GSRQSHNSHQ SLNSLVTISS NHVPENFSLE LTHATPAVEQ VSQLLSMLHQ
   841  GQYQPRPSFR GNKYSRSYRY ALQDMDKFSL KDSGRGDSEA GDSDYDLGRD SPIDRLLGEG
   901  FSDLFLTDGR IPAAMRLCTE ECRVLGHSDQ CWMPPLPSPS SDYRSNMFIP GEEFPTQPQQ
   961  QHPHQSLEDD AQPADSGEKK KSFSTFGKDS PNDEDTGDTS TSSLLSEMSS VFQRLLPPSL
  1021  DTYSECSEVD RSNSLERRKG PLPAKTVGYP QGVAAWAAST HFQNPTTNCG PPLGTHSSVQ
  1081  PSSKWLPAME EIPENYEEDD FDNVLNHLND GKHELMDASE LVAEINKLLQ DVRQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCDH18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

placenta: 42 nTPM
ovary: 38 nTPM
endometrium: 29 nTPM
cervix: 24 nTPM
tongue: 22 nTPM
gallbladder: 21 nTPM

Single-cell type

retinal pigment epithelial cells: 107 nCPM
fibroblasts: 72 nCPM
endometrial stromal cells: 65 nCPM
peritubular myoid cells: 63 nCPM
adipocytes: 59 nCPM
pericytes: 48 nCPM

Immune cell

memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 11 nTPM
hypothalamus: 8.7 nTPM
medulla oblongata: 7.4 nTPM
thalamus: 6.9 nTPM
pons: 6.8 nTPM
spinal cord: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.13
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCDH18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DAB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCDH18 as an antibody target. Whether an autoantibody or antibody against PCDH18 could matter depends on whether native PCDH18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCDH18 is annotated at the cell surface, where native PCDH18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PCDH18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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