Seroatlas · Human Serome Atlas

PAIP2B

Polyadenylate-binding protein-interacting protein 2B

Also known as: KIAA1155, PAI2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULR5
Gene: PAIP2B
Ensembl: ENSG00000124374
Chromosome: 2
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q9ULR5|PAIP2B
     1  MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE LQEQDFLDRC
    61  FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD SEDILSKSNL NPDAKEFIPG
   121  EKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAIP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

midbrain: 123 nTPM
spinal cord: 121 nTPM
hippocampal formation: 85 nTPM
amygdala: 83 nTPM
basal ganglia: 69 nTPM
hypothalamus: 62 nTPM

Single-cell type

pancreatic acinar cells: 320 nCPM
late primary spermatocytes: 159 nCPM
salivary acinar cells: 137 nCPM
gastric chief cells: 128 nCPM
esophageal apical cells: 118 nCPM
myonuclei: 102 nCPM

Immune cell

naive B-cell: 2.6 nTPM
memory B-cell: 2.5 nTPM
plasmacytoid DC: 2.3 nTPM
naive CD4 T-cell: 2.1 nTPM
naive CD8 T-cell: 1.9 nTPM
memory CD4 T-cell: 1.3 nTPM

Brain region

white matter: 262 nTPM
basal ganglia: 218 nTPM
pons: 183 nTPM
midbrain: 172 nTPM
medulla oblongata: 170 nTPM
spinal cord: 168 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAIP2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PABPC4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAIP2B as an antibody target. Whether an autoantibody or antibody against PAIP2B could matter depends on whether native PAIP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAIP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAIP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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