Seroatlas · Human Serome Atlas

PABIR2

PABIR family member 2

Also known as: DKFZp686L20116, FAM122B, PBIR2_HUMAN, RP11-308B5.5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z309
Gene: PABIR2
Ensembl: ENSG00000156504
Chromosome: X
Canonical length: 247 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q7Z309|PABIR2
     1  MAQEKMELDL EPDTSYGGTL RRSSSAPLIH GLSDLSQVFQ PYTLRTRRNS TTIMSRHSLE
    61  EGLDMVNRET AHEREMQTAM QISQSWDESL SLSDSDFDKP EKLYSPKRID FTPVSPAPSP
   121  TRGFGKMFVS SSGLPPSPVP SPRRFSRRSQ SPVKCIRPSV LGPLKRKGEM ETESQPKRLF
   181  QGTTNMLSPD AAQLSDLSSC SDILDGSSSS SGLSSDPLAK GSATAESPVA CSNSCSSFIL
   241  MDDLSPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABIR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
bone marrow: 30 nTPM
lymph node: 28 nTPM
ovary: 27 nTPM
basal ganglia: 26 nTPM
spleen: 26 nTPM

Single-cell type

sertoli cells: 134 nCPM
tuft cells: 69 nCPM
megakaryocytes: 56 nCPM
esophageal apical cells: 50 nCPM
granulosa cells: 45 nCPM
monocyte progenitors: 42 nCPM

Immune cell

eosinophil: 2.6 nTPM
plasmacytoid DC: 1.5 nTPM
naive CD8 T-cell: 1.2 nTPM
NK-cell: 1.2 nTPM
MAIT T-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

hypothalamus: 41 nTPM
choroid plexus: 37 nTPM
basal ganglia: 33 nTPM
white matter: 32 nTPM
spinal cord: 32 nTPM
thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.84
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein serine/threonine phosphatase inhibitor activity

Protein domainsUniProt · Pfam · InterPro

PABIR1/2/3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PABIR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABIR2 as an antibody target. Whether an autoantibody or antibody against PABIR2 could matter depends on whether native PABIR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABIR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABIR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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