P2RY6

Protein identityUniProt · HPA

UniProt accession

Q15077

Gene

P2RY6

Ensembl

ENSG00000171631

Chromosome

11

Canonical length

328 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q15077|P2RY6
     1  MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR
    61  TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI
   121  SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL
   181  SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM
   241  AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL
   301  FYFTQKKFRR RPHELLQKLT AKWQRQGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

32 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.88

gnomAD pLI

0

gnomAD missense Z

0.38

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to prostaglandin E stimulus
• cellular response to purine-containing compound
• G protein-coupled receptor signaling pathway
• phagocytosis
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of inositol trisphosphate biosynthetic process
• positive regulation of release of sequestered calcium ion into cytosol
• positive regulation of vascular associated smooth muscle cell proliferation
• transepithelial chloride transport
• cellular response to pyrimidine ribonucleotide

Molecular functions

• G protein-coupled ADP receptor activity
• G protein-coupled receptor activity
• G protein-coupled UDP receptor activity
• G protein-coupled UTP receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• P2Y6 purinoceptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of P2RY6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSE1L
• KPNB1