Seroatlas · Human Serome Atlas

OTUD6A

OTU domain-containing protein 6A

Also known as: DUBA2, FLJ25831, HSHIN6, OTU6A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L8S5
Gene: OTUD6A
Ensembl: ENSG00000189401
Chromosome: X
Canonical length: 288 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q7L8S5|OTUD6A
     1  MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR MEAEMAQKHR
    61  QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER MESEERERQE SIFQAEMSEH
   121  LAGFKREEEE KLAAILGARG LEMKAIPADG HCMYRAIQDQ LVFSVSVEML RCRTASYMKK
   181  HVDEFLPFFS NPETSDSFGY DDFMIYCDNI VRTTAWGGQL ELRALSHVLK TPIEVIQADS
   241  PTLIIGEEYV KKPIILVYLR YAYSLGEHYN SVTPLEAGAA GGVLPRLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUD6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

testis: 4.5 nTPM
bone marrow: 0.6 nTPM
thyroid gland: 0.3 nTPM
choroid plexus: 0.2 nTPM
heart muscle: 0.1 nTPM
retina: 0.1 nTPM

Single-cell type

early primary spermatocytes: 78 nCPM
differentiating spermatogonia: 8.7 nCPM
paneth cells: 3.9 nCPM
late primary spermatocytes: 2.2 nCPM
peritubular myoid cells: 0.3 nCPM
suprabasal keratinocytes: 0.3 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 0.6 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

choroid plexus: 3.2 nTPM
cerebellum: 3.1 nTPM
white matter: 2.8 nTPM
cerebral cortex: 2.7 nTPM
hypothalamus: 2.6 nTPM
medulla oblongata: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0.28
gnomAD missense Z: 1.82
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUD6A as an antibody target. Whether an autoantibody or antibody against OTUD6A could matter depends on whether native OTUD6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUD6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUD6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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