Seroatlas · Human Serome Atlas

OTUD1

OTU domain-containing protein 1

Also known as: DUBA7, OTDC1, OTUD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VV17
Gene
OTUD1
Ensembl
ENSG00000165312
Chromosome
10
Canonical length
481 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q5VV17|OTUD1
     1  MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET GECQPAAAAE
    61  HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC KPPLPPHYTS TAQITVRALG
   121  ADRLLLHGPD PVPGAAGSAA APRGRCLLLA PAPAAPVPPR RGSSAWLLEE LLRPDCPEPA
   181  GLDATREGPD RNFRLSEHRQ ALAAAKHRGP AATPGSPDPG PGPWGEEHLA ERGPRGWERG
   241  GDRCDAPGGD AARRPDPEAE APPAGSIEAA PSSAAEPVIV SRSDPRDEKL ALYLAEVEKQ
   301  DKYLRQRNKY RFHIIPDGNC LYRAVSKTVY GDQSLHRELR EQTVHYIADH LDHFSPLIEG
   361  DVGEFIIAAA QDGAWAGYPE LLAMGQMLNV NIHLTTGGRL ESPTVSTMIH YLGPEDSLRP
   421  SIWLSWLSNG HYDAVFDHSY PNPEYDNWCK QTQVQRKRDE ELAKSMAISL SKMYIEQNAC
   481  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 57 nTPM
  • heart muscle: 35 nTPM
  • skeletal muscle: 25 nTPM
  • stomach: 22 nTPM
  • tongue: 21 nTPM
  • lung: 19 nTPM

Single-cell type

  • microglia: 34 nCPM
  • podocytes: 9.5 nCPM
  • renal connecting tubule cells: 8.4 nCPM
  • renal collecting duct intercalated cells: 6.6 nCPM
  • distal convoluted tubule cells: 6.5 nCPM
  • brain excitatory neurons: 6.4 nCPM

Immune cell

  • basophil: 2.5 nTPM
  • non-classical monocyte: 1.9 nTPM
  • neutrophil: 1.3 nTPM
  • T-reg: 1.3 nTPM
  • naive B-cell: 1.2 nTPM
  • eosinophil: 1 nTPM

Brain region

  • cerebral cortex: 18 nTPM
  • cerebellum: 17 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 16 nTPM
  • hippocampal formation: 15 nTPM
  • choroid plexus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.65
gnomAD missense Z
1.26
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUD1 as an antibody target. Whether an autoantibody or antibody against OTUD1 could matter depends on whether native OTUD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OTUD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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