Seroatlas · Human Serome Atlas

OSGIN1

Oxidative stress-induced growth inhibitor 1

Also known as: BDGI, OKL38, OSGI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJX0
Gene: OSGIN1
Ensembl: ENSG00000140961
Chromosome: 16
Canonical length: 477 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9UJX0|OSGIN1
     1  MSSSRKDHLG ASSSEPLPVI IVGNGPSGIC LSYLLSGYTP YTKPDAIHPH PLLQRKLTEA
    61  PGVSILDQDL DYLSEGLEGR SQSPVALLFD ALLRPDTDFG GNMKSVLTWK HRKEHAIPHV
   121  VLGRNLPGGA WHSIEGSMVI LSQGQWMGLP DLEVKDWMQK KRRGLRNSRA TAGDIAHYYR
   181  DYVVKKGLGH NFVSGAVVTA VEWGTPDPSS CGAQDSSPLF QVSGFLTRNQ AQQPFSLWAR
   241  NVVLATGTFD SPARLGIPGE ALPFIHHELS ALEAATRVGA VTPASDPVLI IGAGLSAADA
   301  VLYARHYNIP VIHAFRRAVD DPGLVFNQLP KMLYPEYHKV HQMMREQSIL SPSPYEGYRS
   361  LPRHQLLCFK EDCQAVFQDL EGVEKVFGVS LVLVLIGSHP DLSFLPGAGA DFAVDPDQPL
   421  SAKRNPIDVD PFTYQSTRQE GLYAMGPLAG DNFVRFVQGG ALAVASSLLR KETRKPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSGIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

liver: 150 nTPM
duodenum: 29 nTPM
adrenal gland: 26 nTPM
skeletal muscle: 22 nTPM
small intestine: 18 nTPM
testis: 15 nTPM

Single-cell type

late spermatids: 528 nCPM
enterocytes: 104 nCPM
hepatocytes: 103 nCPM
early spermatids: 66 nCPM
alveolar cells type 1: 38 nCPM
colonocytes: 38 nCPM

Immune cell

non-classical monocyte: 13 nTPM
intermediate monocyte: 5.5 nTPM
neutrophil: 4.2 nTPM
classical monocyte: 2.2 nTPM
myeloid DC: 1 nTPM
total PBMC: 1 nTPM

Brain region

medulla oblongata: 24 nTPM
pons: 23 nTPM
thalamus: 21 nTPM
midbrain: 21 nTPM
white matter: 21 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: -1.28
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

midbody

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSGIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSGIN1 as an antibody target. Whether an autoantibody or antibody against OSGIN1 could matter depends on whether native OSGIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSGIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSGIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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