Seroatlas · Human Serome Atlas

ORM1

Alpha-1-acid glycoprotein 1

Also known as: A1AG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02763
Gene: ORM1
Ensembl: ENSG00000229314
Chromosome: 9
Canonical length: 201 aa
Protein class: Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P02763|ORM1
     1  MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ
    61  EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL
   121  ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK
   181  DKCEPLEKQH EKERKQEEGE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 42,168 nTPM

Expression across tissuesHPA

Tissue

liver: 42,168 nTPM
bone marrow: 226 nTPM
prostate: 60 nTPM
spleen: 47 nTPM
lung: 27 nTPM
stomach: 19 nTPM

Single-cell type

hepatocytes: 63,161 nCPM
cholangiocytes: 1,037 nCPM
kupffer cells: 773 nCPM
hepatic stellate cells: 387 nCPM
neutrophils: 159 nCPM
alveolar cells type 2: 75 nCPM

Immune cell

neutrophil: 202 nTPM
classical monocyte: 4.3 nTPM
total PBMC: 1.9 nTPM
non-classical monocyte: 1 nTPM
intermediate monocyte: 0.5 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 1 nTPM
cerebral cortex: 0.9 nTPM
basal ganglia: 0.7 nTPM
choroid plexus: 0.6 nTPM
hypothalamus: 0.6 nTPM
spinal cord: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SERPINE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORM1 as an antibody target. Whether an autoantibody or antibody against ORM1 could matter depends on whether native ORM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORM1 is annotated as secreted, so native ORM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ORM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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