OR6P1

Protein identityUniProt · HPA

UniProt accession

Q8NGX9

Gene

OR6P1

Ensembl

ENSG00000186440

Chromosome

1

Canonical length

317 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

Subcellular location

Mid piece,Principal piece

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q8NGX9|OR6P1
     1  MRNLSGGHVE EFVLVGFPTT PPLQLLLFVL FFAIYLLTLL ENALIVFTIW LAPSLHRPMY
    61  FFLGHLSFLE LWYINVTIPR LLAAFLTQDG RVSYVGCMTQ LYFFIALACT ECVLLAVMAY
   121  DRYLAICGPL LYPSLMPSSL ATRLAAASWG SGFFSSMMKL LFISQLSYCG PNIINHFFCD
   181  ISPLLNLTCS DKEQAELVDF LLALVMILLP LLAVVSSYTA IIAAILRIPT SRGRHKAFST
   241  CAAHLAVVVI YYSSTLFTYA RPRAMYTFNH NKIISVLYTI IVPFFNPAIY CLRNKEVKEA
   301  FRKTVMGRCH YPRDVQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

0 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.85

gnomAD pLI

0

gnomAD missense Z

0.17

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detection of chemical stimulus involved in sensory perception of smell

Molecular functions

• G protein-coupled receptor activity
• olfactory receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Olfactory receptor
• GPCR, rhodopsin-like, 7TM
• Olfactory G-protein coupled receptor 1
• Olfactory receptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Olfaction
• Receptor
• Sensory transduction
• Transducer
• Transmembrane
• Transmembrane helix