OR6A2

Protein identityUniProt · HPA

UniProt accession

O95222

Gene

OR6A2

Ensembl

ENSG00000184933

Chromosome

11

Canonical length

327 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>O95222|OR6A2
     1  MEWRNHSGRV SEFVLLGFPA PAPLQVLLFA LLLLAYVLVL TENTLIIMAI RNHSTLHKPM
    61  YFFLANMSFL EIWYVTVTIP KMLAGFVGSK QDHGQLISFE GCMTQLYFFL GLGCTECVLL
   121  AVMAYDRYMA ICYPLHYPVI VSGRLCVQMA AGSWAGGFGI SMVKVFLISG LSYCGPNIIN
   181  HFFCDVSPLL NLSCTDMSTA ELTDFILAIF ILLGPLSVTG ASYVAITGAV MHIPSAAGRY
   241  KAFSTCASHL TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ
   301  EVKRALCCTL HLYQHQDPDP KKASRNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

0 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OR6A2.

Disease | ImmuneIEDB

Conditions an epitope on OR6A2 was assayed in.

• rectum carcinoma in situ T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0.12

gnomAD missense Z

-1.27

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detection of chemical stimulus involved in sensory perception of smell
• sensory perception of smell
• signal transduction

Molecular functions

• G protein-coupled receptor activity
• olfactory receptor activity

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Olfactory receptor
• GPCR, rhodopsin-like, 7TM
• Olfactory G-protein coupled receptor 1
• Olfactory receptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Olfaction
• Receptor
• Sensory transduction
• Transducer
• Transmembrane
• Transmembrane helix