Seroatlas · Human Serome Atlas

OR56B1

Olfactory receptor 56B1

Also known as: O56B1_HUMAN, OR56B1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGI3
Gene: OR56B1
Ensembl: ENSG00000181023
Chromosome: 11
Canonical length: 324 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8NGI3|OR56B1
     1  MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA NTLILIIIWQ
    61  NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV ISLPECFAQI YAIHFFVGME
   121  SGILLCMAFD RYVAICHPLR YPSIVTSSLI LKATLFMVLR NGLFVTPVPV LAAQRDYCSK
   181  NEIEHCLCSN LGVTSLACDD RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA
   241  EAAAKALSTC SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY
   301  ALQTKELRAA FQKVLFALTK EIRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR56B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

spleen: 0.2 nTPM
appendix: 0.1 nTPM
fallopian tube: 0.1 nTPM
lung: 0.1 nTPM
lymph node: 0.1 nTPM
ovary: 0.1 nTPM

Single-cell type

b-cells: 0.8 nCPM
podocytes: 0.8 nCPM
thymocytes: 0.8 nCPM
fibro-adipogenic progenitors: 0.6 nCPM
hematopoietic stem cells: 0.5 nCPM
müller glia: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
medulla oblongata: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
spinal cord: 0.3 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.92
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR56B1 as an antibody target. Whether an autoantibody or antibody against OR56B1 could matter depends on whether native OR56B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR56B1 is annotated at the cell surface, where native OR56B1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR56B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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