Seroatlas · Human Serome Atlas

OR56A5

Olfactory receptor 56A5

Also known as: O56A5_HUMAN, OR56A5P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7T3
Gene: OR56A5
Ensembl: ENSG00000188691
Chromosome: 11
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>P0C7T3|OR56A5
     1  MTLPSNNSTS PVFEFFLICF PSFQSWQHWL SLPLSLLFLL AMGANATLLI TIYLEASLHQ
    61  PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC FLQVFIMNSF LTMESCTFMI
   121  MAYDRYVAIC KPLQYSSIIT DQFVARAAIF VVARNGLLTM PIPILSSRLR YCAGHIIKNC
   181  ICTNVSVSKL SCDDITLNQS YQFVIGWTLL GSDLILIVLS YFFILKTVLR IKGEGDMAKA
   241  LGTCGSHFIL ILFFTTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
   301  EIKQGIQNLL RRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR56A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

late primary spermatocytes: 0.4 nCPM
late spermatids: 0.4 nCPM
early spermatids: 0.2 nCPM
prostatic glandular cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.3 nTPM
cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR56A5 as an antibody target. Whether an autoantibody or antibody against OR56A5 could matter depends on whether native OR56A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR56A5 is annotated at the cell surface, where native OR56A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR56A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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