Seroatlas · Human Serome Atlas

OR56A4

Olfactory receptor 56A4

Also known as: O56A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGH8
Gene: OR56A4
Ensembl: ENSG00000183389
Chromosome: 11
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGH8|OR56A4
     1  MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI TIQLEASLHQ
    61  PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC FLQMFIMNSF LTMESCTFMV
   121  MAYDRYVAIC HPLRYPSIIT DQFVARAVVF VIARNAFVSL PVPMLSARLR YCAGNIIKNC
   181  ICSNLSVSKL SCDDITFNQL YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA
   241  LSTCGSHFIL ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
   301  EIKQGIQNLL KRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR56A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

retina: 0.2 nTPM
bone marrow: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late spermatids: 9.4 nCPM
early spermatids: 5.5 nCPM
hematopoietic stem cells: 0.5 nCPM
myosatellite cells: 0.5 nCPM
neutrophil progenitors: 0.5 nCPM
endometrial secretory cells: 0.3 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2.8 nTPM
cerebral cortex: 2.7 nTPM
white matter: 2.7 nTPM
basal ganglia: 2.4 nTPM
choroid plexus: 2.4 nTPM
amygdala: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.01
gnomAD missense Z: -0.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR56A4 as an antibody target. Whether an autoantibody or antibody against OR56A4 could matter depends on whether native OR56A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR56A4 is annotated at the cell surface, where native OR56A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR56A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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