Seroatlas · Human Serome Atlas

OR56A3

Olfactory receptor 56A3

Also known as: O56A3_HUMAN, OR56A3P, OR56A6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH54
Gene: OR56A3
Ensembl: ENSG00000184478
Chromosome: 11
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NH54|OR56A3
     1  MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL MTIWLEASLH
    61  QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA CFLQMYIMNC FLAMESCTFM
   121  VMAYDRYVAI CHPLRYPSII TDHFVVKAAM FILTRNVLMT LPIPILSAQL RYCGRNVIEN
   181  CICANMSVSR LSCDDVTINH LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK
   241  ALSTCGSHFM LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT
   301  QEIKQGMQRL LKKGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR56A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

late primary spermatocytes: 4.6 nCPM
retinal ganglion cells: 3.9 nCPM
cytotrophoblasts: 3.7 nCPM
early primary spermatocytes: 2.4 nCPM
syncytiotrophoblasts: 2.4 nCPM
migrating cytotrophoblasts: 2.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR56A3 as an antibody target. Whether an autoantibody or antibody against OR56A3 could matter depends on whether native OR56A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR56A3 is annotated at the cell surface, where native OR56A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR56A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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