Seroatlas · Human Serome Atlas

OR56A1

Olfactory receptor 56A1

Also known as: O56A1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGH5
Gene: OR56A1
Canonical length: 318 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR56A1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8NGH5|OR56A1
     1  MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT TLLITIQLEA
    61  SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS FPACFLQMFI MNSFLPMESC
   121  TFMVMAYDRY VAICHPLRYP SIITNQFVAK ASVFIVVRNA LLTAPIPILT SLLHYCGENV
   181  IENCICANLS VSRLSCDNFT LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA
   241  AVKALSTCGS HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG
   301  VRTKEIKQGI QKLLQRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR56A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
bone marrow: 0.2 nTPM
retina: 0.2 nTPM
epididymis: 0.1 nTPM
gallbladder: 0.1 nTPM
lymph node: 0.1 nTPM

Single-cell type

neutrophils: 1.3 nCPM
podocytes: 1.3 nCPM
prostatic glandular cells: 0.6 nCPM
brain inhibitory neurons: 0.4 nCPM
brain excitatory neurons: 0.3 nCPM
endometrial secretory cells: 0.3 nCPM

Immune cell

basophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 3.9 nTPM
cerebellum: 3.8 nTPM
white matter: 3.7 nTPM
basal ganglia: 3.5 nTPM
choroid plexus: 3.5 nTPM
hippocampal formation: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR56A1 as an antibody target. Whether an autoantibody or antibody against OR56A1 could matter depends on whether native OR56A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR56A1 is annotated at the cell surface, where native OR56A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR56A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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