Seroatlas · Human Serome Atlas

OR52N4

Olfactory receptor 52N4

Also known as: O52N4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGI2
Gene: OR52N4
Ensembl: ENSG00000181074
Chromosome: 11
Canonical length: 321 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q8NGI2|OR52N4
     1  MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL IHYEDALHKP
    61  MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL VQMFFTHTFT GMESGVLMLM
   121  ALDRYVAICY PLRYSTILTN PVIAKVGTAT FLRGVLLIIP FTFLTKLLPY CRGNILPHTY
   181  CDHMSVAKLS CGNVKVNAIY GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF
   241  NTCTAHICAI VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK
   301  QIRDCVIRIL SGSKDTKSYS M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52N4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

spleen: 2.7 nTPM
small intestine: 1.6 nTPM
ovary: 1.5 nTPM
lymph node: 1.2 nTPM
epididymis: 1.1 nTPM
tonsil: 1.1 nTPM

Single-cell type

hematopoietic stem cells: 1 nCPM
microglia: 0.9 nCPM
b-cells: 0.7 nCPM
basal prostatic cells: 0.6 nCPM
pericytes: 0.5 nCPM
breast lactating cells: 0.4 nCPM

Immune cell

T-reg: 0.7 nTPM
naive B-cell: 0.4 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

hypothalamus: 1 nTPM
medulla oblongata: 0.8 nTPM
basal ganglia: 0.6 nTPM
cerebral cortex: 0.6 nTPM
midbrain: 0.6 nTPM
spinal cord: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.96
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52N4 as an antibody target. Whether an autoantibody or antibody against OR52N4 could matter depends on whether native OR52N4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52N4 is annotated at the cell surface, where native OR52N4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52N4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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