Seroatlas · Human Serome Atlas

OR52N2

Olfactory receptor 52N2

Also known as: O52N2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGI0
Gene: OR52N2
Ensembl: ENSG00000180988
Chromosome: 11
Canonical length: 321 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q8NGI0|OR52N2
     1  MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL ISHEEALHRP
    61  MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL AQMFFVHMLT GMESGVLMLM
   121  ALDRYVAICY PLRYATILTN PVIAKAGLAT FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY
   181  CDHMSVAKVS CGNFKVNAIY GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF
   241  STCTSHMCSI VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK
   301  QIQEGVIKFL LGDKVSFTYD K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52N2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
adipose tissue: 0.1 nTPM
gallbladder: 0.1 nTPM
small intestine: 0.1 nTPM
spleen: 0.1 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 6.1 nCPM
early spermatids: 4.5 nCPM
retinal ganglion cells: 3.9 nCPM
parietal cells: 1.8 nCPM
hematopoietic stem cells: 1.5 nCPM
neutrophil progenitors: 1.3 nCPM

Immune cell

basophil: 4 nTPM
myeloid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
medulla oblongata: 0.3 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52N2 as an antibody target. Whether an autoantibody or antibody against OR52N2 could matter depends on whether native OR52N2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52N2 is annotated at the cell surface, where native OR52N2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52N2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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