Seroatlas · Human Serome Atlas

OR52N1

Olfactory receptor 52N1

Also known as: O52N1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH53
Gene: OR52N1
Ensembl: ENSG00000181001
Chromosome: 11
Canonical length: 320 aa
Protein class: Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q8NH53|OR52N1
     1  MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL IYCDEALHRP
    61  MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL AQMFFVHTFT GMESGVLMLM
   121  ALDHCVAICF PLRYATILTN SVIAKAGFLT FLRGVMLVIP STFLTKRLPY CKGNVIPHTY
   181  CDHMSVAKIS CGNVRVNAIY GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF
   241  STCTAHFCAI VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
   301  QVRESVIRFF LKGKDNSHNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52N1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

retina: 0.2 nTPM
adipose tissue: 0.1 nTPM
bone marrow: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2.2 nTPM
white matter: 2.1 nTPM
pons: 2 nTPM
cerebral cortex: 1.8 nTPM
basal ganglia: 1.7 nTPM
medulla oblongata: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.11
gnomAD missense Z: -0.54
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52N1 as an antibody target. Whether an autoantibody or antibody against OR52N1 could matter depends on whether native OR52N1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52N1 is annotated at the cell surface, where native OR52N1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52N1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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