Seroatlas · Human Serome Atlas

OR52K2

Olfactory receptor 52K2

Also known as: O52K2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGK3
Gene: OR52K2
Ensembl: ENSG00000181963
Chromosome: 11
Canonical length: 314 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q8NGK3|OR52K2
     1  MSASNITLTH PTAFLLVGIP GLEHLHIWIS IPFCLAYTLA LLGNCTLLLI IQADAALHEP
    61  MYLFLAMLAA IDLVLSSSAL PKMLAIFWFR DREINFFACL AQMFFLHSFS IMESAVLLAM
   121  AFDRYVAICK PLHYTKVLTG SLITKIGMAA VARAVTLMTP LPFLLRCFHY CRGPVIAHCY
   181  CEHMAVVRLA CGDTSFNNIY GIAVAMFIVV LDLLLVILSY IFILQAVLLL ASQEARYKAF
   241  GTCVSHIGAI LAFYTTVVIS SVMHRVARHA APHVHILLAN FYLLFPPMVN PIIYGVKTKQ
   301  IRESILGVFP RKDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

neutrophil: 3.3 nTPM
classical monocyte: 0.9 nTPM
non-classical monocyte: 0.4 nTPM
eosinophil: 0.3 nTPM
intermediate monocyte: 0.3 nTPM
total PBMC: 0.1 nTPM

Brain region

spinal cord: 1.3 nTPM
medulla oblongata: 1.1 nTPM
white matter: 1 nTPM
pons: 0.8 nTPM
thalamus: 0.7 nTPM
cerebral cortex: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -1.88
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52K2 as an antibody target. Whether an autoantibody or antibody against OR52K2 could matter depends on whether native OR52K2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52K2 is annotated at the cell surface, where native OR52K2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52K2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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