Seroatlas · Human Serome Atlas

OR52I2

Olfactory receptor 52I2

Also known as: O52I2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH67
Gene: OR52I2
Canonical length: 350 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR52I2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q8NH67|OR52I2
     1  MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL QSSHLWLAIS
    61  LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD IVMASSVVPK MVSIFCSGDS
   121  SISFSACFTQ MFFVHLATAV ETGLLLTMAF DRYVAICKPL HYKRILTPQV MLGMSMAITI
   181  RAIIAITPLS WMVSHLPFCG SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD
   241  VAFIAASYIL ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP
   301  LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52I2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

mucous neck cells: 0.8 nCPM
myonuclei: 0.4 nCPM
cardiomyocytes: 0.3 nCPM
fibro-adipogenic progenitors: 0.3 nCPM
retinal bipolar cells: 0.3 nCPM
mast cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.8 nTPM
cerebral cortex: 0.4 nTPM
basal ganglia: 0.3 nTPM
midbrain: 0.3 nTPM
pons: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.44
gnomAD missense Z: -0.92

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52I2 as an antibody target. Whether an autoantibody or antibody against OR52I2 could matter depends on whether native OR52I2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52I2 is annotated at the cell surface, where native OR52I2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52I2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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