Seroatlas · Human Serome Atlas

OR52E5

Olfactory receptor 52E5

Also known as: O52E5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH55
Gene: OR52E5
Ensembl: ENSG00000277932
Chromosome: 11
Canonical length: 327 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q8NH55|OR52E5
     1  MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV IQTEQSLHQP
    61  MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI TQMYTIHICT GLESVVLTVT
   121  GIDRYIAICN PLRYSMILTN KVIAILGIVI IVRTLVFVTP FTFLILRLPF CGVRIIPHTY
   181  CEHMGLAKLA CASINVIYGL IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC
   241  GSHVCVMLAF YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE
   301  QVLRILNPKS FWHFDPKRIF HNNSVRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52E5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

syncytiotrophoblasts: 8.3 nCPM
epicardial cells: 4.5 nCPM
extravillous trophoblasts: 4.5 nCPM
retinal ganglion cells: 3.9 nCPM
early primary spermatocytes: 3.7 nCPM
undifferentiated spermatogonia: 3.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.3 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52E5 as an antibody target. Whether an autoantibody or antibody against OR52E5 could matter depends on whether native OR52E5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52E5 is annotated at the cell surface, where native OR52E5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52E5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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