Seroatlas · Human Serome Atlas

OR52E4

Olfactory receptor 52E4

Also known as: O52E4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGH9
Gene: OR52E4
Ensembl: ENSG00000180974
Chromosome: 11
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NGH9|OR52E4
     1  MPSINDTHFY PPFFLLLGIP GLDTLHIWIS FPFCIVYLIA IVGNMTILFV IKTEHSLHQP
    61  MFYFLAMLSM IDLGLSTSTI PKMLGIFWFN LQEISFGGCL LQMFFIHMFT GMETVLLVVM
   121  AYDRFVAICN PLQYTMILTN KTISILASVV VGRNLVLVTP FVFLILRLPF CGHNIVPHTY
   181  CEHRGLAGLA CAPIKINIIY GLMVISYIIV DVILIASSYV LILRAVFRLP SQDVRLKAFN
   241  TCGSHVCVML CFYTPAFFSF MTHRFGQNIP HYIHILLANL YVVVPPALNP VIYGVRTKQI
   301  REQIVKIFVQ KE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52E4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

retina: 0.6 nTPM
epididymis: 0.4 nTPM
skin: 0.4 nTPM
thyroid gland: 0.3 nTPM
bone marrow: 0.2 nTPM
skeletal muscle: 0.2 nTPM

Single-cell type

early spermatids: 1.7 nCPM
late spermatids: 1.5 nCPM
cardiomyocytes: 0.3 nCPM
respiratory ciliated cells: 0.3 nCPM
submucosal glandular cells: 0.3 nCPM
early primary spermatocytes: 0.1 nCPM

Immune cell

basophil: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 8.9 nTPM
white matter: 8.5 nTPM
cerebral cortex: 8 nTPM
basal ganglia: 7.5 nTPM
hippocampal formation: 7.3 nTPM
hypothalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.89
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52E4 as an antibody target. Whether an autoantibody or antibody against OR52E4 could matter depends on whether native OR52E4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52E4 is annotated at the cell surface, where native OR52E4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52E4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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