Seroatlas · Human Serome Atlas

OR52E1

Olfactory receptor 52E1

Also known as: O52E1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NGJ3
Gene
OR52E1
Canonical length
308 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR52E1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q8NGJ3|OR52E1
     1  MNTTLFHPYS FLLLGIPGLE SMHLWVGFPF FAVFLTAVLG NITILFVIQT DSSLHHPMFY
    61  FLAILSSIDP GLSTSTIPKM LGTFWFTLRE ISFEGCLTQM FFIHLCTGME SAVLVAMAYD
   121  CYVAICDPLC YTLVLTNKVV SVMALAIFLR PLVFVIPFVL FILRLPFCGH QIIPHTYGEH
   181  MGIARLSCAS IRVNIIYGLC AISILVFDII AIVISYVQIL CAVFLLSSHD ARLKAFSTCG
   241  SHVCVMLTFY MPAFFSFMTH RFGRNIPHFI HILLANFYVV IPPALNSVIY GVRTKQIRAQ
   301  VLKMFFNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM
  • cerebral cortex: 0 nTPM

Single-cell type

  • retinal bipolar cells: 0.2 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • white matter: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52E1 as an antibody target. Whether an autoantibody or antibody against OR52E1 could matter depends on whether native OR52E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52E1 is annotated at the cell surface, where native OR52E1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR52E1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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