Seroatlas · Human Serome Atlas

OR52B6

Olfactory receptor 52B6

Also known as: O52B6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGF0
Gene: OR52B6
Ensembl: ENSG00000187747
Chromosome: 11
Canonical length: 335 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q8NGF0|OR52B6
     1  MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP FCIMYITALE
    61  GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK ALANLWLGYS LISFDGCLTQ
   121  MFFIHFLFIH SAVLLAMAFD RYVAICSPLR YVTILTSKVI GKIVTAALSH SFIIMFPSIF
   181  LLEHLHYCQI NIIAHTFCEH MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI
   241  LQAVFRLLSQ DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY
   301  VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52B6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

ovary: 0.1 nTPM
pancreas: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

cardiomyocytes: 0.2 nCPM
pericytes: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.5 nTPM
hypothalamus: 1.4 nTPM
medulla oblongata: 1.4 nTPM
midbrain: 1.3 nTPM
cerebral cortex: 1 nTPM
amygdala: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52B6 as an antibody target. Whether an autoantibody or antibody against OR52B6 could matter depends on whether native OR52B6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52B6 is annotated at the cell surface, where native OR52B6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52B6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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