Seroatlas · Human Serome Atlas

OR52A5

Olfactory receptor 52A5

Also known as: O52A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2C5
Gene: OR52A5
Ensembl: ENSG00000171944
Chromosome: 11
Canonical length: 316 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9H2C5|OR52A5
     1  MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI IKYENSLHIP
    61  MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL FQMWLIHSFQ AIESGILLAM
   121  ALDRYVAICI PLRHATIFSQ QFLTHIGLGV TLRAAILIIP SLGLIKCCLK HYRTTVISHS
   181  YCEHMAIVKL ATEDIRVNKI YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA
   241  FNTCIAHICV FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
   301  QIRDHIVKVF FFKKVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR52A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

undifferentiated spermatogonia: 5.1 nCPM
differentiating spermatogonia: 1.2 nCPM
foveolar cells: 0.6 nCPM
müller glia: 0.6 nCPM
bergmann glia: 0.3 nCPM
cdc: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.8 nTPM
white matter: 0.2 nTPM
basal ganglia: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.88
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR52A5 as an antibody target. Whether an autoantibody or antibody against OR52A5 could matter depends on whether native OR52A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR52A5 is annotated at the cell surface, where native OR52A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR52A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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