Seroatlas · Human Serome Atlas

OR51V1

Olfactory receptor 51V1

Also known as: O51V1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2C8
Gene: OR51V1
Canonical length: 321 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR51V1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9H2C8|OR51V1
     1  MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG NCMVLHVIWT
    61  EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE ISLDSCIAQS YFIHGLSFME
   121  SSVLLTMAFD RYIAICNPLR YSSILTNSRI IKIGLTIIGR SFFFITPPII CLKFFNYCHF
   181  HILSHSFCLH QDLLRLACSD IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ
   241  EERHKLFQTC ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
   301  YSVKTQQIHT RMLRLFSLKR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51V1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

undifferentiated spermatogonia: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.4 nTPM
cerebellum: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.1 nTPM
amygdala: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -1.49
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51V1 as an antibody target. Whether an autoantibody or antibody against OR51V1 could matter depends on whether native OR51V1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51V1 is annotated at the cell surface, where native OR51V1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51V1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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