Seroatlas · Human Serome Atlas

OR51J1

Olfactory receptor 51J1

Also known as: O51J1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H342
Gene: OR51J1
Canonical length: 316 aa

OverviewNCBI Gene

No narrative summary is available for OR51J1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9H342|OR51J1
     1  MKISNNSLGF LPTTFILVGI PGLESEHLWI SVPFSLIYII IFLGNGIILH VIRTDIALHQ
    61  PMYLFLAMLA LAEVRVSAST LPTVLGIFLF GNTEISLEAC LFPDVLHPFF IHDGASCAAG
   121  HVFGPLYSHL QPTELHSYPD TAQGLWHRSY YRTEKHYAHG SVAHSLMASA LLWPQCPLTF
   181  LLSAPQSYLS CGNISVNNIY GIFIVTSTFG LDSLLIVISY GLILHTVLGI ATGEGRKKAL
   241  NTCGSHVCAV LAYYVPMIGL SIVHRLGHRV SPLLQAMMAN AYLFFPPVVN PIVYSIKTKE
   301  IHGAIVRMLL EKRRRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51J1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.38

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.43
gnomAD missense Z: 0.31

OntologyGO

Biological processes

sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51J1 as an antibody target. Whether an autoantibody or antibody against OR51J1 could matter depends on whether native OR51J1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51J1 is annotated at the cell surface, where native OR51J1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51J1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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