Seroatlas · Human Serome Atlas

OR51I2

Olfactory receptor 51I2

Also known as: O51I2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H344
Gene: OR51I2
Ensembl: ENSG00000187918
Chromosome: 11
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q9H344|OR51I2
     1  MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR VEPSLHEPMY
    61  YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ MFLIHFFSMM ESGILLAMSF
   121  DRYVAICDPL RYATVLTTEV IAAMGLGAAA RSFITLFPLP FLIKRLPICR SNVLSHSYCL
   181  HPDMMRLACA DISINSIYGL FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT
   241  CVSHILAVLA FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR
   301  RAIFRMFHHI KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51I2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

epicardial cells: 6.8 nCPM
hematopoietic stem cells: 4.9 nCPM
retinal ganglion cells: 3.9 nCPM
medullary thymic epithelial cells: 2.4 nCPM
adipocytes: 1.7 nCPM
granulosa cells: 1.6 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.9 nTPM
amygdala: 0.8 nTPM
hypothalamus: 0.8 nTPM
midbrain: 0.8 nTPM
white matter: 0.8 nTPM
pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.04
gnomAD missense Z: -1.5
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51I2 as an antibody target. Whether an autoantibody or antibody against OR51I2 could matter depends on whether native OR51I2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51I2 is annotated at the cell surface, where native OR51I2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51I2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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